Sound trailers work well on continuous circuit layouts, with or without hidden sidings, because each train is usually running in the same direction each time it runs.
However, end to end layouts are more difficult. A sound trailer can be placed between the loco and its train and all will be well as it runs from one end to the other. But what happens when the train is reversed to run in the opposite direction; the soundcard is now at the wrong end of the train.
On a small, station to fiddle yard layout, the best solution is probably to use a layout sound system under the baseboards. By using multiple speakers, which can be switched in and out, the sound can then “move” with the loco.
On a larger layout, with a branch line and terminus, then a sound trailer should work well in an auto-train since the loco always stays at the same end, next to the soundcard in the coach. In goods trains, a soundcard in a goods van would work as long as the loco always took the van with it when shunting. The bigger problem is passenger trains made up of several coaches which the loco will “run around” at the terminus and then pull them out in the opposite direction. A solution would be to install a “reversible” sound system in each rake of coaches, as described below.